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KMID : 1161420170200030235
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Journal of Medicinal Food
2017 Volume.20 No. 3 p.235 ~ p.242
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Antihyperglycemic Effect of Quercetin in Ovariectomized Rats Treated with Tamoxifen
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Silva Fernanda Coleraus
Bramatti Isabella Calvo
Toledo Adrieli Gorlin
Salles Fernando Marques
Itinose Ana Maria
Marek Carla Brugin
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Abstract
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Tamoxifen is effective in breast cancer therapy in postmenopausal women; however, it causes adverse effects that alter the glycolytic pathway and induce hyperglycemia. Quercetin, a flavonoid with antioxidant potential, inhibits butyrylcholinesterase (BuChE), which is positively associated with hyperglycemia. Therefore, this study investigated the effect of quercetin on tamoxifen-induced hyperglycemia, using BuChE activity as a bioindicator in adult ovariectomized Wistar rats. The ovariectomized rats were treated orally for 14 days with different concentrations of quercetin (2.5, 7.5, 22.5, and 67.5?mg.kg?1 b.w.) and tamoxifen (5?mg.kg?1 b.w.). Subsequently, they were euthanized; blood and tissue samples were collected. The following biochemical parameters were analyzed: plasma glucose levels and BuChE activity in the plasma, liver, intestine, and adipose tissue. The most effective dose of quercetin in reducing hyperglycemia was 22.5?mg.kg?1 b.w. (Que/TAM 4.5/1, P??.05). In summary, the findings of the present study suggest that quercetin when associated with tamoxifen decreases in plasma glucose levels. Furthermore, in these cases, BuChE should not be used as an indicator of hyperglycemia.
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KEYWORD
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butyrylcholinesterase, diabetes, flavonoids, SERM
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